The regiment was raised in Northern England by Colonel William Whitmore as the 55th Regiment of Foot for service in the Seven Years' War. It was re-ranked as the 53rd Regiment of Foot, following the disbandment of the existing 50th and 51st regiments, in 1756. The regiment departed Ireland for North America in April 1776 and arrived at Quebec City in May 1776 to help raise the siege of the city by Continental Army troops during the American Revolutionary War. It served under Sir Guy Carleton at the Battle of Trois-Rivières in June 1776 and the Battle of Valcour Island in October 1776. Its flank companies were with General John Burgoyne during the ill-fated Saratoga campaign. Men from the other eight companies served under Major Christopher Carleton of the 29th Regiment of Foot during Carleton's Raid in 1778 and during the Burning of the Valleys campaign in 1780. Lieutenant Richard Houghton of the 53rd led the Royalton raid in 1780 burning three towns in eastern Vermont. In 1782 the regiment adopted a county designation and became the 53rd (the Shropshire) Regiment of Foot. The regiment returned to England in 1789.