The 6th Maryland Regiment was organized on March 27, 1776 composed of eight companies of volunteers from Prince Georges, Queen Anne's, Frederick, Cecil, Harford, and Anne Arundel counties in the colony of Maryland. The Regiment was authorized on September 16, 1776 in the Continental Army as the 6th Maryland Regiment. It was assigned on December 27, 1776 to the Main Continental Army. It was assigned on May 22, 1777 to the 2nd Maryland Brigade, an element of the Main Continental Army. Tt was re-organized to nine companies on 12 May 1779. The 2d Maryland Brigade was re-assigned to the Southern Department on 5 April 1780. The regiment was disbanded on January 1, 1783 at Annapolis, Maryland.