The Chatham County Regiment was a unit of the North Carolina militia that served during the American Revolution. The North Carolina General Assembly authorized the Chatham County Regiment on September 9, 1775, along with 34 other county regiments. The officers were appointed and commissioned by the Governor of North Carolina. The regiment was subordinated to the Hillsboro District Brigade of North Carolina militia on May 4, 1776. The regiment was disbanded at the end of the war.