The Regiment was authorized on September 16, 1776 in the Continental Army as the 10th Pennsylvania Regiment. It was assigned on December 27, 1776 to the Main Continental Army. Organized in spring 1777 at Philadelphia to consist of 8 companies from York, Bucks, Northampton and Northumberland Counties. It was assigned on May 22, 1777 to the 1st Pennsylvania Brigade, an element of the Main Army. Captain Jacob Weaver's Independent Company consolidated on November 7, 1777 with the 10th Pennsylvania Regiment. Consolidated and reorganized on July 1, 1778 with the 11th Pennsylvania Regiment and redesignated as the 10th Pennsylvania Regiment, to consist of 9 companies. The regiment would see action during the Battle of Brandywine, Battle of Germantown, Battle of Monmouth and the Battle of Springfield. The regiment was disbanded on January 17, 1781 at Trenton, New Jersey.