The Regiment was authorized on June 6, 1775 in the South Carolina State Troops as the 2d South Carolina Regiment. Organized in summer 1775 at Charleston to consist of ten companies from eastern South Carolina. It was assigned on June 15, 1779 to McIntosh’s Brigade, an element of the Southern Department. Consolidated on February 11, 1780 with the 6th South Carolina Regiment and consolidated unit designated as the 2nd South Carolina Regiment, to consist of nine companies; concurrently relieved from Huger’s Brigade and assigned to the South Carolina Brigade, an element of the Southern Department. Captured on May 12, 1780 at Charleston by the British Army. Disbanded on January 1, 1783.